Safe and Responsible use of psychedelic medicine involves practical strategies to promote safety and well-being. Key practices include starting with low doses to minimize the risk of overdose and avoiding using drugs alone so someone is present in an emergency. Using clean equipment for every use helps prevent infections and other health issues. It’s vital to avoid mixing drugs, as different substances can interact in unpredictable and dangerous ways. Staying hydrated, taking breaks, and knowing where to access support or emergency help are important, too. These harm reduction steps empower individuals to make safer choices by reducing risks and maximizing benefits when taking psychedelic medicine.